解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:Importance:Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2017.0056
更新日期:2017-05-01 00:00:00
abstract:Importance:Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in ...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2017.0025
更新日期:2017-04-01 00:00:00
abstract:Importance:Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical symptoms, etiological models suggest that the biological male phenotype carries a higher intrins...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.3990
更新日期:2017-04-01 00:00:00
abstract:Importance:Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferior frontal gyrus (IFG)-one node in a corticothalamic inhibitory control (IC) network. Objective:To examine associations between IC neural circuitry structure and function and lapse/relapse vulnerability in 2 inde...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2017.0017
更新日期:2017-04-01 00:00:00
abstract:Importance:A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolida...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.3907
更新日期:2017-03-01 00:00:00
abstract:Importance:Although several strategies of repetitive transcranial magnetic stimulation (rTMS) have been investigated as treatment of major depressive disorder (MDD), their comparative efficacy and acceptability is unknown. Objective:To establish the relative efficacy and acceptability of the different modalities of rT...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamapsychiatry.2016.3644
更新日期:2017-02-01 00:00:00
abstract:Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.1870
更新日期:2016-10-01 00:00:00
abstract:Importance:Epidemiologic evidence indicates that most of the general population will experience a mental health disorder at some point in their lives. However, few prospective population-based studies have estimated trajectories of risk for mental disorders from young through middle adulthood to estimate the proportion...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.1921
更新日期:2016-10-01 00:00:00
abstract:Importance:More than 30 million people live with a stroke diagnosis worldwide. Depression after stroke is frequent, and greater knowledge of associated risk factors and outcomes is needed to understand the etiology and implications of this disabling complication. Objectives:To examine whether the incidence of and risk...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.1932
更新日期:2016-10-01 00:00:00
abstract:IMPORTANCE:At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other neurodevelopmental disorders, such as intellectual disability. It is possible that additional intellectual disability-associated CNVs increase the risk for...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.1831
更新日期:2016-09-01 00:00:00
abstract:IMPORTANCE:Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities. OBJECTIVE:To establish shared and...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析
doi:10.1001/jamapsychiatry.2016.0700
更新日期:2016-08-01 00:00:00
abstract:IMPORTANCE:Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly. OBJECTIVE:To undertake a systematic review and meta-an...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamapsychiatry.2016.0934
更新日期:2016-08-01 00:00:00
abstract:IMPORTANCE:The requirement of a childhood onset has always been a key criterion for the diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults, but recently this requirement has become surrounded by controversy. OBJECTIVE:To investigate whether impaired young adults with ADHD symptoms always have a chi...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.0383
更新日期:2016-07-01 00:00:00
abstract:IMPORTANCE:Compulsory admissions, defined as admissions against the will of the patient (according to local judicial procedures), have a strong effect on psychiatric patients. In several Western countries, the rate of such admissions is tending to rise. Its reduction is urgently needed. OBJECTIVE:To establish which in...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamapsychiatry.2016.0501
更新日期:2016-07-01 00:00:00
abstract:IMPORTANCE:After major policy changes in the United States, policymakers, health care professionals, and the general public seek information about whether recreational cannabis use is associated with physical health problems later in life. OBJECTIVE:To test associations between cannabis use over 20 years and a variety...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2016.0637
更新日期:2016-07-01 00:00:00
abstract:IMPORTANCE:Cannabis dependence (CAD) is a serious problem worldwide and is of growing importance in the United States because cannabis is increasingly available legally. Although genetic factors contribute substantially to CAD risk, at present no well-established specific genetic risk factors for CAD have been elucidat...
journal_title:JAMA psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapsychiatry.2016.0036
更新日期:2016-05-01 00:00:00
abstract:IMPORTANCE:Developmental brain disorders are a group of clinically and genetically heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic causes can often be shared by a subset of individuals with different phenotypic features, and recent advances in genome sequencing have allowed...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.2692
更新日期:2016-03-01 00:00:00
abstract:IMPORTANCE:Community functioning is a core component of the functional deficits in schizophrenia, yet little systematic research on the origins of these functional deficits has been performed. OBJECTIVES:To examine 3 key domains of community functioning--social activity, independent behavior, and functioning in school...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.2253
更新日期:2016-01-01 00:00:00
abstract:IMPORTANCE:The 16p11.2 BP4-BP5 duplication is the copy number variant most frequently associated with autism spectrum disorder (ASD), schizophrenia, and comorbidities such as decreased body mass index (BMI). OBJECTIVES:To characterize the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthro...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.2123
更新日期:2016-01-01 00:00:00
abstract:IMPORTANCE:Sedentary behaviors and physical inactivity are not only increasing worldwide but also are critical risk factors for adverse health outcomes. Yet, few studies have examined the effects of sedentary behavior on cognition or the long-term role of either behavior in early to middle adulthood. OBJECTIVE:To inve...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.2468
更新日期:2016-01-01 00:00:00
abstract:IMPORTANCE:Mental health (MH) conditions are undertreated in late life. It is important to identify treatment strategies that address variability in treatment content and delivery and take individual-specific symptoms into account, particularly among low-income, community-dwelling older adults. OBJECTIVE:To evaluate p...
journal_title:JAMA psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamapsychiatry.2015.2157
更新日期:2015-12-01 00:00:00
abstract:IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.2079
更新日期:2015-12-01 00:00:00
abstract:IMPORTANCE:Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood. OBJECTIVES:To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize thei...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析
doi:10.1001/jamapsychiatry.2015.1376
更新日期:2015-10-01 00:00:00
abstract:IMPORTANCE:In schizophrenia, working memory deficits appear to reflect abnormalities in the generation of gamma oscillations in the dorsolateral prefrontal cortex. The generation of gamma oscillations requires the phasic excitation of inhibitory parvalbumin-containing interneurons. Thus, gamma oscillations depend, in p...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.0533
更新日期:2015-08-01 00:00:00
abstract:IMPORTANCE:National epidemiologic information from recently collected data on the new DSM-5 classification of alcohol use disorder (AUD) using a reliable, valid, and uniform data source is needed. OBJECTIVE:To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, associated...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.0584
更新日期:2015-08-01 00:00:00
abstract::Neural oscillations are rhythmic fluctuations over time in the activity or excitability of single neurons, local neuronal populations or "assemblies," and/or multiple regionally distributed neuronal assemblies. Synchronized oscillations among large numbers of neurons are evident in electrocorticographic, electroenceph...
journal_title:JAMA psychiatry
pub_type: 杂志文章,评审
doi:10.1001/jamapsychiatry.2015.0483
更新日期:2015-08-01 00:00:00
abstract:IMPORTANCE:Serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. Serotonin 1A autoreceptors, which inhibit serotonin synthesis and release, are downregulated in SAD, and...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.0125
更新日期:2015-08-01 00:00:00
abstract:IMPORTANCE:Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each exposure individually. OBJECTIVE:To examine the risk for all-cause dement...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2015.0082
更新日期:2015-06-01 00:00:00
abstract:IMPORTANCE:Studies have shown that the scientific literature has overestimated the efficacy of antidepressants for depression, but other indications for these drugs have not been considered. OBJECTIVE:To examine reporting biases in double-blind, placebo-controlled trials on the pharmacologic treatment of anxiety disor...
journal_title:JAMA psychiatry
pub_type: 杂志文章,meta分析
doi:10.1001/jamapsychiatry.2015.15
更新日期:2015-05-01 00:00:00
abstract:IMPORTANCE:The continuum view of the psychosis spectrum (PS) implies that, in population-based samples, PS symptoms should be associated with neural abnormalities similar to those found in help-seeking clinical risk individuals and in schizophrenia. To our knowledge, functional neuroimaging has not previously been appl...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.3169
更新日期:2015-05-01 00:00:00
abstract:IMPORTANCE:Posttraumatic stress disorder (PTSD) is a common, debilitating mental disorder that has been associated with type 2 diabetes mellitus (T2D) and its risk factors, including obesity, in cross-sectional studies. If PTSD increases risk of incident T2D, enhanced surveillance in high-risk populations may be warran...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.2632
更新日期:2015-03-01 00:00:00
abstract:IMPORTANCE:In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South ...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.2433
更新日期:2015-02-01 00:00:00
abstract:IMPORTANCE:Recent estimates indicate that 6.5 million adolescents and young adults in the United States are neither in school nor working. These youth have significant mental health concerns that require intervention. OBJECTIVE:To determine whether a mental health intervention, integrated into an employment training p...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.2022
更新日期:2015-01-01 00:00:00
abstract:IMPORTANCE:The inverse social gradient in mental disorders is a well-established research finding with important implications for causal models and policy. This research has used traditional objective social status (OSS) measures, such as educational level, income, and occupation. Recently, subjective social status (SS...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.1337
更新日期:2014-12-01 00:00:00
abstract:IMPORTANCE:Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of...
journal_title:JAMA psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamapsychiatry.2014.1025
更新日期:2014-11-01 00:00:00
abstract:IMPORTANCE:The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. OBJECTIVES:First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to diff...
journal_title:JAMA psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapsychiatry.2014.1100
更新日期:2014-11-01 00:00:00
abstract:IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.1079
更新日期:2014-10-01 00:00:00
abstract:IMPORTANCE:Adverse childhood experiences (ACEs) are associated with several adulthood health problems, such as self-directed violence. For some individuals, enlistment in the military may be an instrumental act to escape adverse household environments; however, to our knowledge prevalence of ACEs among persons with a h...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.724
更新日期:2014-09-01 00:00:00
abstract:IMPORTANCE:Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia. OBJECTIVE:To eval...
journal_title:JAMA psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamapsychiatry.2014.1105
更新日期:2014-09-01 00:00:00
abstract:IMPORTANCE:Depression and obesity are 2 prevalent disorders that have been repeatedly shown to be associated. However, the mechanisms and temporal sequence underlying this association are poorly understood. OBJECTIVE:To determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, ...
journal_title:JAMA psychiatry
pub_type: 杂志文章
doi:10.1001/jamapsychiatry.2014.411
更新日期:2014-08-01 00:00:00